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1 Auxilliary pumping system
2 LineaseptaTM bag pump
3 Septum connection feed
4 Vibrator
5 Membrane of pulsation chamber
6 Pulsation chamber
7 Nozzle plate
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8 Bypass system with CIP
9 CIP system connection
10 Reaction vessel
11 Stirrer
12 Septum hardening solution feed
13 Bottom valve
14 Filtration unit hardening solution
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Short description
The small sterile plant with 13 nozzles meets the requirements of industrial production of small batches. The plant can be adjusted to the changing users requirements. The modular design approach allows to combine equipment delivered by Nisco with components already available in the user's facility.
Applications
For a large number of applications (e.g. enzyme/drug immobilisation, cell encapsulation, cosmetic applications and many more), microencapsulation opens new technological possibilities.
Principle
The Lineasepta TM bag pump produces a steady pulsation-free flow to the vibrating chamber. The beat generating unit has 13 nozzles. The vibration is superimposed on the product feed in the vibrating chamber by means of a membrane (frequency and amplitude can be adjusted digitally). The generated drops can be observed by means of an LED-stroboscopic light as 13 stationary chains of parallel drops. The stroboscopic light is automatically synchronised with the adjusted vibration frequency. Monodisperse beads of the size between 0.2 and 1.5mm can be generated. The deviation between the applications mainly depend on the viscosity and the surface tension of the matrix. Roughly you can estimate that the smallest achievable drop diameter is 1.5 to 2 times larger than the used nozzle diameter. The average productivity per nozzle is 400ml per hour, whereas it can significantly differ in function of the nozzle diameter and the jet speed. The unit can be sterilised in an autoclave. The typical batch size is 1 to 2 litre.
Control cabinet
Rack with display, four lines x 16 characters, programmable micro controller for vibration control and stroboscopic light.
Power supply between 110 V and 240 Volt, automatic adjusting.
Papers for Download
