Tricyclic antidepressants (TCAs) are a group of drugs that contain a characteristic three ringed nucleus structure. TCAs work by inhibiting the reuptake of serotonin and norepinephrine back into brain cells and are rapidly absorbed and have a long half-life. TCAs drugs include Amitriptyline, Amoxapine, Desipramine, Doxepin, Imipramine, Nortriptyline, Proptriptyline and Trimipramine. They have been used in the treatment of various forms of depression, anxiety disorders, attention deficit hyperactivity disorder and enuresis in children. TCA antidepressant drugs are among the most toxic and commonly encountered causes of self-poisoning compared to other types of antidepressants.
Cross Reactivity
| Analyte |
Compound |
Cross Reactivity %
|
| TCAs (Tricyclic Antidepressants)
LOD: 10.9 ng/mL
|
Nortriptyline |
100 |
|
Imipramine N-oxide
|
1127
|
|
N-desmethyl Trimipramine
|
396.5
|
|
|
Imipramine
|
294
|
|
|
Trimipramine
|
238
|
|
|
Desipramine
|
206
|
|
|
Cyclobenzaprine
|
201
|
|
|
Amitriptyline
|
190
|
|
|
Opipramol
|
167
|
|
|
Promazine
|
117
|
|
|
Maprotiline
|
96
|
|
|
Doxepine
|
95
|
|
|
Clomipramine
|
76
|
|
|
Protriptyline
|
67
|
|
|
Northiaden (Nordothiepin)
|
63.2
|
|
|
Cyproheptadine
|
61
|
|
|
Lofepramine
|
58
|
|
|
Dothiepin
|
50
|
|
|
Chlorpromazine
|
24.3
|
|
|
Norclomipramine HCI
|
22.1
|
|
|
2-Hydroxy imipramine
|
19.5
|
|
|
Nordoxepin
|
19.4
|
|
|
Perphenazine
|
17.3
|
|
|
Prochlorperazine
|
9.3
|
|
|
10-OH amitriptyline
|
6.4
|
|
|
2-OH desipramine
|
5.1
|
|
|
Quetiapine Fumarate
|
4.5
|
|
|
Thioridazine HCI
|
0.5
|
|
|
Carbamazepine
|
0.3
|
|
|
Cetirizine diHCI
|
0.3
|
|
|
Orphenadrine HCI
|
0.2
|
|
|
Amoxapine
|
0.1
|
|
|
Hydroxyzine diHCI
|
<0.1
|
|
|
Oxcarbazepine
|
<0.1
|
|
|
Diphenhydramine HCI
|
<0.1
|
|
|
Carbam,azepine 10,11 epoxide
|
<0.1
|
|
|
10-Hydroxynortriptyline
|
<0.1
|
|
|
Iminostilbene
|
<0.1
|
|
|
Mianserin
|
<0.1
|
| |
|
