Synthetic Cannabinoids are chemical compounds that mimic the effects of THC, the main active ingredient of cannabis. They bind to the cannabinoid receptors in the brain and were developed to treat pain. The two most common synthetic cannabinoids were JWH-018 and JWH-073. New versions of these include AM1248, AKB48, UR144 and XLR11. UR144 and XLR11 are the new generation of synthetic cannabinoids and are chemically different to the first generation. New generations of synthetic cannabinoids are continuously emerging to replace the synthetic cannabinoids that have been made illegal. The napthlene ring in JWH-018 is substituted with a tetramethylcyclopropyl group to form UR144. XLR11 is the fluorinated version of UR144.
Cross Reactivity
| Analyte |
Compound |
Cross Reactivity %
|
| Synthetic Cannabinoids UR144/XLR11
LOD: 0.27 ng/mL
|
UR144 N-Pentanoic Acid |
100 |
|
A-834735
|
111
|
|
UR144 N-(5-hydroxypentyl) metabolite
|
110
|
|
|
UR144 N-(4-hydroxypentyl) metabolite
|
107
|
|
|
A796260
|
88
|
|
|
UR144 N-(5-hydroxypentyl) β-D-Glucuronide
|
81
|
|
|
AB-005
|
47
|
|
|
XLR11 N-(3-fluoropentyl) isomer
|
29
|
|
|
XLR11
|
29
|
|
|
XLR11 N-(4-pentenyl) analog
|
26
|
|
|
UR144
|
19
|
|
|
XLR11 N-(2-fluoropentyl) isomer
|
16
|
|
|
UR144 N-(5-bromopentyl) analog
|
15
|
|
|
UR144 N-(5-chloropentyl) analog
|
13
|
|
|
UR144 Desalkyl
|
13
|
|
|
UR144 N-(heptyl) analog
|
6
|
|
|
XLR11 Degradant
|
3
|
|
|
UR144 Degradant
|
2
|
|
|
XLR11 N-(4-hydroxypentyl) metabolite
|
2
|
|
|
STS135
|
<1
|
|
|
AKB48 N-(5-fluoropentyl) analog
|
<1
|
|
|
AKB48
|
<1
|
|
|
AM-1248
|
<1
|
|
|
PB-22 3-Carboxy indole
|
<1
|
