Methamphetamine is a Central Nervous System (CNS) stimulant that causes hypertension and tachycardia with feelings of increased confidence, sociability and energy. Acute intoxication causes serious cardiovascular disturbances as well as behavioural problems. Methamphetamine is metabolized in the liver by aromatic hydroxylation, N-dealkylation, and deamination; at least 7 metabolites have been identified in urine. The half-life of methamphetamine is 4 to 5 hours. Following oral administration of methamphetamine hydrochloride, approximately 62% of the administered dose is excreted in urine within the first 24 hours, with metabolites and unchanged drug accounting for about two-thirds and one-third, respectively, of the recovered drug.
Cross Reactivity
| Analyte |
Compound |
Cross Reactivity %
|
| 'Benzo Fury' |
5-MAPB HCI |
146.5 |
|
5-MAPDB HCI
|
41.8
|
|
6-APB HCI
|
1.1
|
|
|
5-APB HCI
|
<1
|
|
|
5-APDB HCI
|
<1
|
|
|
5-IT
|
<1
|
| Cathinone/Bath Salts |
Methylone HCI |
<1 |
|
R(+)Methcathinone HCO
|
<1
|
|
S(-)Fluoromethcathinone HCI
|
<1
|
|
|
3-Fluoromethcathinone HCI
|
<1
|
|
|
Methylethcathinone
|
<1
|
|
|
N-Ethylcathinone HCI
|
<1
|
|
|
Ethylone HCI
|
<1
|
|
|
Buphedrone HCI
|
<1
|
|
|
MDPBP HCI
|
<1
|
|
|
MDPV HCI
|
<1
|
|
|
Naphyrone HCI
|
<1
|
|
|
MDPPP HCI
|
<1
|
|
|
Cathinone
|
<1
|
|
|
Butylone
|
<1
|
|
|
Flephedrone HCI
|
<1
|
|
|
Methedrone
|
<1
|
| Designed Amphetamine Analogues |
DOB |
<1 |
|
DOM
|
<1
|
|
DOET
|
<1
|
|
|
TMA
|
<1
|
|
|
2C-E
|
<1
|
|
|
2C-B
|
<1
|
|
|
2C-1
|
<1
|
| Methamphetamine
LOD: 0 ng/mL
|
(+)-Methamphetamine |
100 |
|
PMMA HCI
|
157.5
|
|
S(+)-Methamphetamine
|
83.9
|
|
|
MDMA
|
83.7
|
|
|
(±)-Methamphetamine
|
40.4
|
|
|
MDEA
|
2.8
|
|
|
BDB
|
1.1
|
|
|
d-Amphetamine
|
<1
|
|
|
I-Amphetamine
|
<1
|
|
|
(±)-Amphetamne
|
<1
|
|
|
S(+)-Amphetamine
|
<1
|
|
|
R(-)-Amphetamine
|
<1
|
|
|
R(-)-Methamphetamine
|
<1
|
|
|
I-Methamphetamine HCI
|
<1
|
|
|
(±) -MDA
|
<1
|
|
|
(±)-MBDB HCI
|
<1
|
|
|
Phentermine
|
<1
|
|
|
TFMPP
|
<1
|
|
|
PMA HCI
|
<1
|
|
|
(1S,2S)-(+)-Pseudoephedrine
|
0.2
|
|
|
Methylphenidate
|
<1
|
|
|
Ephedrine
|
<1
|
