| Product Code | 11024 |
| Bead Size | 300-500µm |
| Matrix Structure | 4% agarose, hardened |
| Flow rate | 5000cm/h* |
| Binding Capacity | 50mg BSA/ml resin |
| Cleaning | 0.5M NaOH |
| Storage Conditions | 20% ethanol, 2-8C |
| Temperature stability range | 2°-121°C |
| Functional ligand | -SO3 |
| Ion Exchanger Type | Strong cation |
| pH stability range | 2-14 |
| Coupling conditions | Dependent on target functional group |
| Chemical stability | Common aqueous, organic, high salt, denaturants |
| Physical stability | Negligible volumbe changes due to pH or Ionic state |
| Drug master file | U.S. Food & Drug Administration |
*Flow rate determined in a 1.5x5cm column
- Large particle diameter allows crude material to pass through the column with little to no backpressure during direct capture
- Highly robust, chemically stable beads are ideal for process-scale separations
- High product recovery, up to 95%
-cGMP manufacturing; Regulatory Support File available
-DMF with USFDA
SP Cellthru BigBead Plus is a large particle, strong cation exchanger. The strong ion exchange beads stay charged and maintain high capacities over a wide working pH range. In weak ion exchangers, capacity is a function of pH.
Ion exchange Cellthru BigBead Plus resins are made of a hardened agarose matrix with ion exchange groups attached through a spacer arm. Hardening increases the chemical and mechanical stability of the matrix.
Cellthru BigBeads are used for viscous feed streams and direct capture in standard packed-bed applications using specially manufactured columns. Scale up from pilot to production scale follows a linear relationship, reducing the time spent on method development.
